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Semaglutide (Wegovy, Ozempic) is a medicine used for weight loss in specific patients, and to lower blood sugar levels and reduce the risk of major cardiovascular events such as heart attack or stroke in type two diabetes patients. Semaglutide is a GLP-1 agonist and works by increasing insulin release, lowering the amount of glucagon released, delaying gastric emptying and reducing appetite.
Semaglutide is not for use in people with type 1 diabetes.
Each of the different brands of semaglutide (Wegovy, Ozempic, Rybelus) are FDA approved for different conditions.
Used to help control blood sugar levels in type 2 diabetic patients, it is used together with diet and exercise. It is also used to reduce the risk of major cardiac events such as heart attack and strokes in type 2 diabetic patients who already have cardiovascular disease. Used for weight loss for patients who have an initial BMI (body mass index) of 30kg/m2 or greater or patients who have a BMI of 27kg/m2 or greater and also have least one weight-related condition, such as high blood pressure, type 2 diabetes and high cholesterol. It is use together with diet and exercise.
Here’s how semaglutide helps with weight loss:
- Appetite suppression: Semaglutide acts on receptors in the brain that regulate appetite and food intake. It helps reduce hunger and increase satiety, making people feel fuller for longer periods and reducing their desire to eat.
- Delayed gastric emptying: Semaglutide slows down the rate at which food leaves the stomach, leading to increased feelings of fullness and reduced food consumption.
- Reduced calorie intake: By decreasing appetite and increasing satiety, semaglutide helps people consume fewer calories overall, which can contribute to weight loss.
- Weight loss maintenance: Semaglutide helps in sustaining weight loss over time. Studies have shown that people who use semaglutide for weight management are more likely to maintain their weight loss compared to those who do not use it.
Semaglutide side effects
Get emergency medical help if you have signs of an allergic reaction: hives, itching; dizziness, fast heartbeats; difficult breathing; swelling of your face, lips, tongue, or throat.
Serious side effects of semaglutide may include:
- vision changes;
- unusual mood changes, thoughts about hurting yourself;
- pounding heartbeats or fluttering in your chest;
- a light-headed feeling, like you might pass out;
- signs of a thyroid tumor–swelling or a lump in your neck, trouble swallowing, a hoarse voice, feeling short of breath;
- symptoms of pancreatitis–severe pain in your upper stomach spreading to your back, nausea with or without vomiting, fast heart rate
- gallbladder problems–upper stomach pain, fever, clay-colored stools, jaundice (yellowing of the skin or eyes);
- low blood sugar – headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery;
- kidney problems–swelling, urinating less, feeling tired or short of breath; or
- stomach flu symptoms–stomach cramps, vomiting, loss of appetite, diarrhea (may be watery or bloody).
Common side effects of semaglutide may include:
- low blood sugar (in people with type 2 diabetes);
- stomach issues
- nausea, vomiting, stomach pain, loss of appetite;
- diarrhea or constipation
- stomach flu symptoms; o
- headache, dizziness, tiredness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.